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RAGs and regulation of autoantibodies

Jankovic, Mila and Casellas, Rafael and Yannoutsos, Nikos and Wardemann, ­Hedda and Nussenzweig, Michel C. (2004) RAGs and regulation of autoantibodies. Annual Review of Immunology, 22 . pp. 485-501. ISSN 0732-0582.

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Autoreactive antibodies are etiologic agents in a number of autoimmune diseases. Like all other antibodies these antibodies are produced in developing B cells by V(D)J recombination in the bone marrow. Three mechanisms regulate autoreactive B cells: deletion, receptor editing, and anergy. Here we review the prevalence of autoantibodies in the initial antibody repertoire, their regulation by receptor editing, and the role of the recombinase proteins (RAG l and RAG2) in this process.

Item Type:Article
Additional Information:"Reprinted, with permission, from the Annual Review of Immunology, Volume 22 copyright 2004 by Annual Reviews," First published online as a Review in Advance on November 10, 2003.
Subject Keywords:B cell development; tolerance; receptor editing; RAG1 and RAG2 expression; antiself antibodies
Record Number:CaltechAUTHORS:JANari04
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1655
Deposited By: Tony Diaz
Deposited On:13 Feb 2006
Last Modified:26 Dec 2012 08:45

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