Farin, Azadeh and Liu, Charles Y. and Langmoen, Iver A. and Apuzzo, Michael L. J. (2009) Biological restoration of central nervous system architecture and function: Part 3 – Stem cell- and cell-based applications and realities in the biological management of central nervous system disorders: traumatic, vascular, and epilepsy disorders. Neurosurgery, 65 (5). pp. 831-859. ISSN 0148-396X http://resolver.caltech.edu/CaltechAUTHORS:20091106-140422267
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Stem cell therapy has emerged as a promising novel therapeutic endeavor for traumatic brain injury, spinal cord injury, stroke, and epilepsy in experimental studies. A few preliminary clinical trials have further supported its safety and early efficacy after transplantation into humans. Although not yet clinically available for central nervous system disorders, stem cell technology is expected to evolve into one of the most powerful tools in the biological management of complex central nervous system disorders, many of which currently have limited treatment modalities. The identification of stem cells, discovery of neurogenesis, and application of stem cells to treat central nervous system disorders represent a dramatic evolution and expansion of the neurosurgeon's capabilities into the neurorestoration and neuroregeneration realms. In Part 3 of a 5-part series on stem cells, we discuss the theory, experimental evidence, and clinical data pertaining to the use of stem cells for the treatment of traumatic, vascular, and epileptic disorders.
|Additional Information:||© 2009 Congress of Neurological Surgeons. Received, February 18, 2009. Accepted, April 24, 2009. NLM Journal Code: nzl, 7802914. The authors have no personal financial or institutional interest in any of the drugs, materials, or devices described in this article.|
|Subject Keywords:||Cellular neurosurgery; Epilepsy; Molecular neurosurgery; Neural restoration; Spinal cord injury; Stem cell; Stroke; Traumatic brain injury|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||16 Nov 2009 22:48|
|Last Modified:||26 Dec 2012 11:32|
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