Fingler, Jeff and Zawadzki, Robert J. and Werner, John S. and Schwartz, Dan and Fraser , Scott E. (2009) Volumetric microvascular imaging of human retina using optical coherence tomography with a novel motion contrast technique. Optics Express, 17 (24). pp. 22190-22200. ISSN 1094-4087 http://resolver.caltech.edu/CaltechAUTHORS:20091221-101539421
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Phase variance-based motion contrast imaging is demonstrated using a spectral domain optical coherence tomography system for the in vivo human retina. This contrast technique spatially identifies locations of motion within the retina primarily associated with vasculature. Histogram-based noise analysis of the motion contrast images was used to reduce the motion noise created by transverse eye motion. En face summation images created from the 3D motion contrast data are presented with segmentation of selected retinal layers to provide non-invasive vascular visualization comparable to currently used invasive angiographic imaging. This motion contrast technique has demonstrated the ability to visualize resolution-limited vasculature independent of vessel orientation and flow velocity.
|Additional Information:||© 2009 Optical Society of America. Received 27 Aug 2009; revised 6 Oct 2009; accepted 6 Nov 2009; published 19 Nov 2009. Help from Susan Garcia and Suman Pilli from UC Davis Eye Center, Sacramento, CA is appreciated. This research was partially supported by NIH grant EY014743.|
|Classification Code:||OCIS codes: (110.4500) Optical coherence tomography; (120.5050) Phase measurement; (170.3880) Medical and biological imaging; (170.4500) Optical coherence tomography.|
|Official Citation:||Jeff Fingler, Robert J. Zawadzki, John S. Werner, Dan Schwartz, and Scott E. Fraser, "Volumetric microvascular imaging of human retina using optical coherence tomography with a novel motion contrast technique," Opt. Express 17, 22190-22200 (2009) http://www.opticsinfobase.org/abstract.cfm?URI=oe-17-24-22190|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||05 Jan 2010 00:32|
|Last Modified:||26 Dec 2012 11:39|
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