Puckett, Cindy A. and Ernst, Russell J. and Barton, Jacqueline K. (2010) Exploring the cellular accumulation of metal complexes. Dalton Transactions, 39 (5). pp. 1159-1170. ISSN 1477-9234 http://resolver.caltech.edu/CaltechAUTHORS:20100216-153031939
- Published Version
See Usage Policy.
Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:20100216-153031939
Transition metal complexes offer great potential as diagnostic and therapeutic agents, and a growing number of biological applications have been explored. To be effective, these complexes must reach their intended target inside the cell. Here we review the cellular accumulation of metal complexes, including their uptake, localization, and efflux. Metal complexes are taken up inside cells through various mechanisms, including passive diffusion and entry through organic and metal transporters. Emphasis is placed on the methods used to examine cellular accumulation, to identify the mechanism(s) of uptake, and to monitor possible efflux. Conjugation strategies that have been employed to improve the cellular uptake characteristics of metal complexes are also described.
|Additional Information:||© 2010 Royal Society of Chemistry. Received 23rd October 2009; accepted 11th November 2009; first published as an Advance Article on the web 23rd December 2009. Financial support for this work from the National Institutes of Health (Grant GM33309 to J.K.B.) is acknowledged.|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Jason Perez|
|Deposited On:||17 Feb 2010 00:38|
|Last Modified:||26 Dec 2012 11:46|
Repository Staff Only: item control page