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The Effect of Spatially Inhomogeneous Extracellular Electric Fields on Neurons

Anastassiou, Costas A. and Montgomery, Sean M. and Barahona, Mauricio and Buzsáki, György and Koch, Christof (2010) The Effect of Spatially Inhomogeneous Extracellular Electric Fields on Neurons. Journal of Neuroscience, 30 (5). pp. 1925-1936. ISSN 0270-6474. http://resolver.caltech.edu/CaltechAUTHORS:20100225-084528690

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Abstract

The cooperative action of neurons and glia generates electrical fields, but their effect on individual neurons via ephaptic interactions is mostly unknown. Here, we analyze the impact of spatially inhomogeneous electric fields on the membrane potential, the induced membrane field, and the induced current source density of one-dimensional cables as well as morphologically realistic neurons and discuss how the features of the extracellular field affect these quantities. We show through simulations that endogenous fields, associated with hippocampal theta and sharp waves, can greatly affect spike timing. These findings imply that local electric fields, generated by the cooperative action of brain cells, can influence the timing of neural activity.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1523/JNEUROSCI.3635-09.2010 DOIArticle
http://www.jneurosci.org/cgi/content/abstract/30/5/1925PublisherArticle
http://www.ncbi.nlm.nih.gov/pubmed/20130201PubMed CentralArticle
Additional Information:© 2010 the authors. Received July 15, 2009; revised Nov. 10, 2009; accepted Dec. 8, 2009. This work was supported by the Engineering and Physical Sciences Research Council, the Swiss National Foundation, and the National Science Foundation (via a collaborative grant between G.B. and C.K.).Wethank Simal Ozen, Joshua Milstein, and Ueli Rutishauser for ideas and discussions, Ted Carnevale for discussions regarding the numerical implementation and help with NEURON, and Karthik Sarma for numerical procedures and the movies.
Group:Koch Laboratory, KLAB
Funders:
Funding AgencyGrant Number
Engineering and Physical Sciences Research Council (EPSRC)UNSPECIFIED
Swiss National FoundationUNSPECIFIED
NSFUNSPECIFIED
Record Number:CaltechAUTHORS:20100225-084528690
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20100225-084528690
Official Citation:Costas A. Anastassiou, Sean M. Montgomery, Mauricio Barahona, György Buzsáki, and Christof Koch The Effect of Spatially Inhomogeneous Extracellular Electric Fields on Neurons J. Neurosci. 30: 1925-1936; doi:10.1523/JNEUROSCI.3635-09.2010
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:17587
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:02 Mar 2010 23:58
Last Modified:25 Nov 2015 20:15

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