Esplin, Taran L. and Cable, Morgan L. and Gray, Harry B. and Ponce, Adrian (2010) Terbium-Macrocycle Complexes as Chemical Sensors: Detection of an Aspirin Metabolite in Urine Using a Salicylurate-Specific Receptor Site. Inorganic Chemistry, 49 (10). pp. 4643-4647. ISSN 0020-1669 http://resolver.caltech.edu/CaltechAUTHORS:20100610-083640997
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Salicylurate (SU) is the major metabolite in urine of acetylsalicylic acid (aspirin) and can be used as a metric to monitor aspirin pharmacokinetics and as an indicator of appendicitis, anemia, and liver disease. Detection in urine and plasma currently requires solvent extraction or other sample handling prior to analysis. We present a simple method to quantify SU in urine via chelation to a terbium binary complex with the macrocycle 1,4,7,10-tetraazacyclododecane-1,7-bisacetate (DO2A). Binding of SU to form the [Tb(DO2A)(SU)]− ternary complex triggers intense luminescence under UV excitation due to an absorbance-energy transfer-emission mechanism. Here we report characterization of the [Tb(DO2A)(SU)]− ternary complex and application of this sensitized lanthanide luminescence method to quantify SU in urine samples following a low-dose aspirin regimen.
|Additional Information:||© 2010 American Chemical Society. Received February 13, 2010. Publication Date (Web): April 21, 2010. The authors thank Mona Shahgholi for assistance withmass spectrometry. This research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under contract with the National Aeronautic and Space Administration and was sponsored by the NASA Astrobiology and Planetary Protection Programs (A.P.), the Department of Homeland Security Chemical and Biological Research & Development Program (A.P.), the NASA Graduate Student Research Program (M.L.C.), and the NASA Undergraduate Student Research Program (T.L.E.). Work at the Beckman Institute was supported by the NIH, NSF, and the Arnold and Mabel Beckman Foundation (H.B.G.).|
|Official Citation:||Terbium-Macrocycle Complexes as Chemical Sensors: Detection of an Aspirin Metabolite in Urine Using a Salicylurate-Specific Receptor Site Taran L. Esplin, Morgan L. Cable, Harry B. Gray, Adrian Ponce Inorganic Chemistry 2010 49 (10), 4643-4647|
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|Deposited By:||Tony Diaz|
|Deposited On:||13 Jun 2010 03:56|
|Last Modified:||26 Dec 2012 12:07|
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