Nahmad, Marcos and Stathopoulos, Angelike (2010) Establishing positional information through gradient dynamics: a lesson from the Hedgehog signaling pathway. Fly, 4 (4). pp. 273-277. ISSN 1933-6934 http://resolver.caltech.edu/CaltechAUTHORS:20101213-114114987
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A longstanding question in developmental biology is how morphogen gradients establish positional information during development. Although the existence of gradients and their role in developmental patterning is no longer in doubt, the ability of cells to respond to different morphogen concentrations has been controversial. In the Drosophila wing disc, Hedgehog (Hh) forms a concentration gradient along the anterior-posterior axis and establishes at least three different gene expression patterns. In a recent study, we challenged the prevailing idea that Hh establishes positional information in a dose-dependent manner and proposed a model in which dynamics of the gradient, resulting from the Hh gene network architecture, determines pattern formation in the wing disc. In this Extra View, we discuss further the methodology used in this study, highlight differences between this and other models of developmental patterning, and also present some questions that remain to be answered in this system.
|Additional Information:||© 2010 Landes Bioscience. Submitted: 04/06/10; Revised: 06/11/10; Accepted: 06/15/10.|
|Subject Keywords:||Hedgehog; developmental patterning; morphogen; dynamics; mathematical modeling|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||14 Dec 2010 20:37|
|Last Modified:||26 Dec 2012 12:45|
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