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Sindbis virus proteins nsP1 and nsP2 contain homology to nonstructural proteins from several RNA plant viruses

Ahlquist, Paul and Strauss, Ellen G. and Rice, Charles M. and Strauss, James H. and Haseloff, James and Zimmern, David (1985) Sindbis virus proteins nsP1 and nsP2 contain homology to nonstructural proteins from several RNA plant viruses. Journal of Virology, 53 (2). pp. 536-642. ISSN 0022-538X. PMCID PMC254668. http://resolver.caltech.edu/CaltechAUTHORS:AHLjvir85

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Abstract

Although the genetic organization of tobacco mosaic virus (TMV) differs considerably from that of the tripartite viruses (alfalfa mosaic virus [AlMV] and brome mosaic virus [BMV]), all of these RNA plant viruses share three domains of homology among their nonstructural proteins. One such domain, common to the AlMV and BMV 2a proteins and the readthrough portion of TMV p183, is also homologous to the readthrough protein nsP4 of Sindbis virus (Haseloff et al., Proc. Natl. Acad. Sci. U.S.A. 81:4358-4362, 1984). Two more domains are conserved among the AlMV and BMV 1a proteins and TMV p126. We show here that these domains have homology with portions of the Sindbis proteins nsP1 and nsP2, respectively. These results strengthen the view that the four viruses share mechanistic similarities in their replication strategies and may be evolutionarily related. These results also suggest that either the AlMV 1a, BMV 1a, and TMV p126 proteins are multifunctional or Sindbis proteins nsP1 and nsP2 function together as subunits in a single complex.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://www.ncbi.nlm.nih.gov/pmc/articles/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC254668//PubMed CentralArticle
Additional Information:Copyright © 1985, American Society for Microbiology Received 2 August 1984/Accepted 12 October 1984 This work was supported by Public Health Service grants AI-1466, AI-15342, AI-10793, and AI-20612 from the National Institutes of Health and by a grant (PCM-8316856) from the National Science Foundation.
Funders:
Funding AgencyGrant Number
NIHAI 1466
NIHAI 15342
NIHAI 10793
NIHAI 20612
NSFPCM-8316856
PubMed Central ID:PMC254668
Record Number:CaltechAUTHORS:AHLjvir85
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:AHLjvir85
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ID Code:2141
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:11 Mar 2006
Last Modified:15 Dec 2015 22:53

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