Frydman, Cary and Camerer, Colin F. and Bossaerts, Peter and Rangel, Antonio (2011) MAOA-L carriers are better at making optimal financial decisions under risk. Proceedings of the Royal Society of London. Series B, Biological Sciences, 278 (1714). pp. 2053-2059. ISSN 0962-8452 http://resolver.caltech.edu/CaltechAUTHORS:20101220-110227095
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Genes can affect behaviour towards risks through at least two distinct neurocomputational mechanisms: they may affect the value assigned to different risky options, or they may affect the way in which the brain adjudicates between options based on their value. We combined methods from neuroeconomics and behavioural genetics to investigate the impact that the genes encoding for monoamine oxidase-A (MAOA), the serotonin transporter (5-HTT) and the dopamine D4 receptor (DRD4) have on these two computations. Consistent with previous literature, we found that carriers of the MAOA-L polymorphism were more likely to take financial risks. Our computational choice model, rooted in established decision theory, showed that MAOA-L carriers exhibited such behaviour because they are able to make better financial decisions under risk, and not because they are more impulsive. In contrast, we found no behavioural or computational differences among the 5-HTT and DRD4 polymorphisms.
|Additional Information:||© 2010 The Royal Society. Received October 22, 2010. Accepted November 12, 2010. Advance online article: Published online before print December 8, 2010. Financial support from Betty and Gordon Moore Foundation (A.R., C.C.) is gratefully acknowledged.|
|Subject Keywords:||neuroeconomics, behavioural genetics, monoamine oxidase-A, risk-taking, decision-making|
|Official Citation:||* Cary Frydman, * Colin Camerer, * Peter Bossaerts, * and Antonio Rangel MAOA-L carriers are better at making optimal financial decisions under riskProc. R. Soc. B published online before print December 8, 2010, doi:10.1098/rspb.2010.2304|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||20 Dec 2010 20:02|
|Last Modified:||26 Dec 2012 12:46|
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