Takahashi, Hidehiko and Matsui, Hiroshi and Camerer, Colin F. and Takano, Harumasa and Kodaka, Fumitoshi and Ideno, Takashi and Okubo, Shigetaka and Takemura, Kazuhisa and Arakawa, Ryosuke and Eguchi, Yoko and Murai, Toshiya and Okubo, Yoshiro and Kato, Motoichiro and Ito, Hiroshi and Suhara, Tetsuya (2010) Dopamine D_1 Receptors and Nonlinear Probability Weighting in Risky Choice. Journal of Neuroscience, 30 (49). pp. 16567-16572. ISSN 0270-6474 http://resolver.caltech.edu/CaltechAUTHORS:20110111-113830801
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Misestimating risk could lead to disadvantaged choices such as initiation of drug use (or gambling) and transition to regular drug use (or gambling). Although the normative theory in decision-making under risks assumes that people typically take the probability-weighted expectation over possible utilities, experimental studies of choices among risks suggest that outcome probabilities are transformed nonlinearly into subjective decision weights by a nonlinear weighting function that overweights low probabilities and underweights high probabilities. Recent studies have revealed the neurocognitive mechanism of decision-making under risk. However, the role of modulatory neurotransmission in this process remains unclear. Using positron emission tomography, we directly investigated whether dopamine D_1 and D_2 receptors in the brain are associated with transformation of probabilities into decision weights in healthy volunteers. The binding of striatal D_1 receptors is negatively correlated with the degree of nonlinearity of weighting function. Individuals with lower striatal D_1 receptor density showed more pronounced overestimation of low probabilities and underestimation of high probabilities. This finding should contribute to a better understanding of the molecular mechanism of risky choice, and extreme or impaired decision-making observed in drug and gambling addiction.
|Additional Information:||© 2010 The Authors. Received July 28, 2010; revised Sept. 12, 2010; accepted Oct. 8, 2010. This study was supported by a consignment expense for Molecular Imaging Program on “Research Base for PET Diagnosis” from the Ministry of Education, Culture, Sports, Science and Technology (MEXT). We thank Katsuyuki Tanimoto and Takahiro Shiraishi for their assistance in performing the PET experiments at the National Institute of Radiological Sciences. We also thank Yoshiko Fukushima of the National Institute of Radiological Sciences for her help as clinical research coordinator.|
|Official Citation:||Takahashi, H., H. Matsui, et al. (2010). "Dopamine D1 Receptors and Nonlinear Probability Weighting in Risky Choice." J. Neurosci. 30(49): 16567-16572.|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Jason Perez|
|Deposited On:||26 Jan 2011 22:54|
|Last Modified:||26 Dec 2012 12:50|
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