Fong, Eileen and Tirrell, David A. (2010) Collective Cell Migration on Artificial Extracellular Matrix Proteins Containing Full-Length Fibronectin Domains. Advanced Materials, 22 (46). 5271-5275 . ISSN 0935-9648 http://resolver.caltech.edu/CaltechAUTHORS:20110202-085127824
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Protein-based biomaterials that promote rapid wound healing are prepared by expression of artificial genes in bacterial cells. Artificial extracellular matrix proteins containing full-length fibronectin domains 9 and 10 exhibit strong α_5β_1 integrin binding and support rapid spreading, proliferation, and collective migration of fibroblasts.
|Additional Information:||© 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: July 7, 2010; Revised: August 11, 2010; Published online: September 30, 2010. The authors thank Drs. Stacey Maskarinec and Shelly Tzlil for discussions. We acknowledge Dr. Anand Asthagiri for Rat-1 fi broblasts and generous access to the fl uorescence microscope. E. F. is supported in part by the Nanyang Overseas Scholarship, Singapore. This work is supported by NIH EB001971, by the NSF Center for Science and Engineering of Materials, and by the Armed Forces Institute for Regenerative Medicine Wake Forest–Pittsburgh Consortium.|
|Subject Keywords:||wound healing; extracellular matrices; artificial proteins; hybrid materials|
|Official Citation:||Fong, E. and Tirrell, D. A. (2010), Collective Cell Migration on Artificial Extracellular Matrix Proteins Containing Full-Length Fibronectin Domains. Advanced Materials, 22: 5271–5275. doi: 10.1002/adma.201002448|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||14 Feb 2011 21:41|
|Last Modified:||14 Feb 2011 21:41|
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