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Neural Systems Responding to Degrees of Uncertainty in Human Decision-Making

Hsu, Ming and Bhatt, Meghana and Adolphs, Ralph and Tranel, Daniel and Camerer, Colin F. (2005) Neural Systems Responding to Degrees of Uncertainty in Human Decision-Making. Science, 310 (5754). pp. 1680-1683. ISSN 0036-8075. http://resolver.caltech.edu/CaltechAUTHORS:20110203-153438545

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Abstract

Much is known about how people make decisions under varying levels of probability (risk). Less is known about the neural basis of decision-making when probabilities are uncertain because of missing information (ambiguity). In decision theory, ambiguity about probabilities should not affect choices. Using functional brain imaging, we show that the level of ambiguity in choices correlates positively with activation in the amygdala and orbitofrontal cortex, and negatively with a striatal system. Moreover, striatal activity correlates positively with expected reward. Neurological subjects with orbitofrontal lesions were insensitive to the level of ambiguity and risk in behavioral choices. These data suggest a general neural circuit responding to degrees of uncertainty, contrary to decision theory.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.1115327 DOIUNSPECIFIED
http://www.sciencemag.org/content/310/5754/1680.fullPublisherUNSPECIFIED
Additional Information:© 2005 American Association for the Advancement of Science. Received 26 May 2005; accepted 20 October 2005. We thank K. Scheer and M. Koenigs for data collection, and P. Bossaerts and S. Quartz for valuable input in the planning stages of this work. Supported by NSF grant SES 0433010 (C.C. and R.A.), the MacArthur Foundation Preferences Network (C.C.), Caltech grant CFC.PROVOST- 3-GRANT (C.C.), NIH grants R01 MH067681 (R.A.) and P01 NS19632 (D.T.), and the David and Lucile Packard Foundation.
Funders:
Funding AgencyGrant Number
NSFSES 0433010
MacArthur Foundation Preferences Network UNSPECIFIED
CaltechCFC.PROVOST-3-GRANT
NIHR01 MH067681
NIHP01 NS19632
David and Lucile Packard FoundationUNSPECIFIED
Record Number:CaltechAUTHORS:20110203-153438545
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20110203-153438545
Official Citation:Hsu, M., M. Bhatt, et al. (2005). "Neural Systems Responding to Degrees of Uncertainty in Human Decision-Making." Science 310(5754): 1680-1683.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:21992
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:14 Feb 2011 19:42
Last Modified:14 Feb 2011 19:42

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