Jenison, Rick L. and Rangel, Antonio and Oya, Hiroyuki and Kawasaki, Hiroto and Howard, Matthew A. (2011) Value Encoding in Single Neurons in the Human Amygdala during Decision Making. Journal of Neuroscience, 31 (1). pp. 331-338. ISSN 0270-6474 http://resolver.caltech.edu/CaltechAUTHORS:20110207-085255266
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A growing consensus suggests that the brain makes simple choices by assigning values to the stimuli under consideration and then comparing these values to make a decision. However, the network involved in computing the values has not yet been fully characterized. Here, we investigated whether the human amygdala plays a role in the computation of stimulus values at the time of decision making. We recorded single neuron activity from the amygdala of awake patients while they made simple purchase decisions over food items. We found 16 amygdala neurons, located primarily in the basolateral nucleus that responded linearly to the values assigned to individual items.
|Additional Information:||© 2011 the authors. Received Aug. 25, 2010; revised Oct. 20, 2010; accepted Oct. 26, 2010. This work was supported by the National Institute on Alcohol Abuse and Alcoholism and Collaborative Research in Computational Neuroscience Grant R01AA018736 (R.L.J., A.R., M.A.H.), National Science Foundation Grant SES- 0820316 (R.L.J.), National Institutes of Health Grants R01DC04290 (M.A.H.), MO1RR59 (General Clinical Research Centers Program, M.A.H.), the Hoover Fund (M.A.H.), and the Carver Trust (M.A.H.).|
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|Deposited By:||Tony Diaz|
|Deposited On:||21 Jun 2011 22:56|
|Last Modified:||26 Dec 2012 12:54|
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