Pathak, Siddhartha and Swadener, J. Gregory and Kalidindi, Surya R. and Courtland, Hayden-William and Jepsen, Karl J. and Goldman, Haviva M. (2011) Measuring the dynamic mechanical response of hydrated mouse bone by nanoindentation. Journal of the Mechanical Behavior of Biomedical Materials , 4 (1). pp. 34-43. ISSN 1751-6161 http://resolver.caltech.edu/CaltechAUTHORS:20110223-093925509
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This study demonstrates a novel approach to characterizing hydrated bone's viscoelastic behavior at lamellar length scales using dynamic indentation techniques. We studied the submicron-level viscoelastic response of bone tissue from two different inbred mouse strains, A/J and B6, with known differences in whole bone and tissue-level mechanical properties. Our results show that bone having a higher collagen content or a lower mineral-to-matrix ratio demonstrates a trend towards a larger viscoelastic response. When normalized for anatomical location relative to biological growth patterns in the antero-medial (AM) cortex, bone tissue from B6 femora, known to have a lower mineral-to-matrix ratio, is shown to exhibit a significantly higher viscoelastic response compared to A/J tissue. Newer bone regions with a higher collagen content (closer to the endosteal edge of the AM cortex) showed a trend towards a larger viscoelastic response. Our study demonstrates the feasibility of this technique for analyzing local composition-property relationships in bone. Further, this technique of viscoelastic nanoindentation mapping of the bone surface at these submicron length scales is shown to be highly advantageous in studying subsurface features, such as porosity, of wet hydrated biological specimens, which are difficult to identify using other methods.
|Additional Information:||© 2010 Elsevier Ltd. Received 20 May 2010; revised 30 August 2010; accepted 5 September 2010. Available online 16 September 2010. This work was supported by grants from the National Institutes of Health (NIH AR044927). S.P. wishes to acknowledge the support from the 2007 Sigma Xi Grants-in-Aid of Research (GIAR) program and the 2007 Center for Integrated Nanotechnologies (CINT) user proposal grant for use of facilities at the Los Alamos National Laboratory, Los Alamos, NM. Thanks also to Phil Nasser at MSSM for assistance with sample preparation, and to Ryan J. Stromberg at Hysitron Inc. for help with the nano-DMA® technique.|
|Subject Keywords:||Bone; Viscoelasticity; Nanoindentation|
|Official Citation:||Siddhartha Pathak, J. Gregory Swadener, Surya R. Kalidindi, Hayden-William Courtland, Karl J. Jepsen, Haviva M. Goldman, Measuring the dynamic mechanical response of hydrated mouse bone by nanoindentation, Journal of the Mechanical Behavior of Biomedical Materials, Volume 4, Issue 1, January 2011, Pages 34-43, ISSN 1751-6161, DOI: 10.1016/j.jmbbm.2010.09.002. (http://www.sciencedirect.com/science/article/B8G3J-511K43X-1/2/b78f816cbc5025484fa7696b3a8d0aab)|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Ruth Sustaita|
|Deposited On:||23 Feb 2011 21:09|
|Last Modified:||23 Feb 2011 21:10|
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