Fujibayashi, Kenichi and Hariadi, Rizal and Park, Sung Ha and Winfree, Erik and Murata, Satoshi (2008) Toward reliable algorithmic self-assembly of DNA tiles: A fixed-width cellular automaton pattern. Nano Letters, 8 (7). pp. 1791-1797. ISSN 1530-6984 http://resolver.caltech.edu/CaltechAUTHORS:20110309-104158035
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Bottom-up fabrication of nanoscale structures relies on chemical processes to direct self-assembly. The complexity, precision, and yield achievable by a one-pot reaction are limited by our ability to encode assembly instructions into the molecules themselves. Nucleic acids provide a platform for investigating these issues, as molecular structure and intramolecular interactions can encode growth rules. Here, we use DNA tiles and DNA origami to grow crystals containing a cellular automaton pattern. In a one-pot annealing reaction, 250 DNA strands first assemble into a set of 10 free tile types and a seed structure, then the free tiles grow algorithmically from the seed according to the automaton rules. In our experiments, crystals grew to ~300 nm long, containing ~300 tiles with an initial assembly error rate of ~1.4% per tile. This work provides evidence that programmable molecular self-assembly may be sufficient to create a wide range of complex objects in one-pot reactions.
|Additional Information:||© 2008 American Chemical Society. Received September 7, 2007; Revised Manuscript Received October 10, 2007. Publication Date (Web): December 28, 2007. This work was supported by Grant-in-Aid for Scientific Research on Priority Areas (No. 17059001) from MEXT and Grant-in-Aid for Scientific Research (A) (No. 19200023) from JSPS to S.M., JSPS Research Fellowships for Young Scientists (No. 05697) to K.F., with additional support from NSF Grants (Nos. 0432193, 0093486) to E.W., and a Center for the Physics of Information postdoctoral fellowship to S.H.P.|
|Official Citation:||Toward Reliable Algorithmic Self-Assembly of DNA Tiles: A Fixed-Width Cellular Automaton Pattern Kenichi Fujibayashi, Rizal Hariadi, Sung Ha Park, Erik Winfree, and Satoshi Murata Nano Letters 2008 8 (7), 1791-1797|
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|Deposited By:||Lucinda Acosta|
|Deposited On:||20 Oct 2011 18:48|
|Last Modified:||26 Dec 2012 13:00|
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