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DNA hybridization catalysts and catalyst circuits

Seelig, Georg and Yurke, Bernard and Winfree, Erik (2005) DNA hybridization catalysts and catalyst circuits. In: DNA Computing. Lecture Notes in Computer Science. No.3384. Springer , Berlin , pp. 329-343. ISBN 3-540-26174-5

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Practically all of life's molecular processes, from chemical synthesis to replication, involve enzymes that carry out their functions through the catalysis of metastable fuels into waste products. Catalytic control of reaction rates will prove to be as useful and ubiquitous in DNA nanotechnology as it is in biology. Here we present experimental results on the control of the decay rates of a metastable DNA "fuel". We show that the fuel complex can be induced to decay with a rate about 1600 times faster than it would decay spontaneously. The original DNA hybridization catalyst [15] achieved a maximal speed-up of roughly 30. The fuel complex discussed here can therefore serve as the basic ingredient for an improved DNA hybridization catalyst. As an example application for DNA hybridization catalysts, we propose a method for implementing arbitrary digital logic circuits.

Item Type:Book Section
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Winfree, Erik0000-0002-5899-7523
Additional Information:© 2005 Springer-Verlag Berlin Heidelberg. Thanks to Ben Rahn, Jeremy Leibs, Joseph Schaeffer, Jongmin Kim, Dave Zhang, and especially Paul Rothemund for stimulating discussion and help preparing figures and simulations. GS was supported by the Swiss National Science Foundation, EW was supported by NSF CAREER Grant No. 0093486, NSF ITR Grant No. 0113443, and GenTel.
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Swiss National Science Foundation (SNSF)UNSPECIFIED
NSF ITR0113443
Record Number:CaltechAUTHORS:20110309-104201845
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:22761
Deposited By: Lucinda Acosta
Deposited On:27 Oct 2011 15:06
Last Modified:07 Mar 2015 00:30

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