Campbell, Bronwyn E. and Boag, Peter R. and Hofmann, Andreas and Cantacessi, Cinzia and Wang, Conan K. and Taylor, Paul and Hu, Min and Sindhu, Zia-ud-Din and Loukas, Alex and Sternberg, Paul W. and Gasser, Robin B. (2011) Atypical (RIO) protein kinases from Haemonchus contortus — Promise as new targets for nematocidal drugs. Biotechnology Advances, 29 (3). pp. 338-350. ISSN 0734-9750 http://resolver.caltech.edu/CaltechAUTHORS:20110518-104531775
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Almost nothing is known about atypical kinases in multicellular organisms, including parasites. Supported by information and data available for the free-living nematode, Caenorhabditis elegans, and other eukaryotes, the present article describes three RIO kinase genes, riok-1, riok-2 and riok-3, from Haemonchus contortus, one of the most important parasitic nematodes of small ruminants. Analyses of these genes and their products predict that they each play critical roles in the developmental pathways of parasitic nematodes. The findings of this review indicate prospects for functional studies of these genes in C. elegans (as a surrogate) and opportunities for the design of a novel class of nematode-specific inhibitors of RIO kinases. The latter aspect is of paramount importance, given the serious problems linked to anthelmintic resistance in parasitic nematode populations of livestock.
|Additional Information:||© 2011 Elsevier Inc. Received 6 September 2010; revised 28 December 2010; accepted 14 January 2011. Available online 22 January 2011. Funding from the Australian Research Council (ARC) is gratefully acknowledged (RBG). PRB is supported by funding from the National Health and Medical Research Council (NHMRC).|
|Subject Keywords:||Parasite; Haemonchus contortus; RIO kinases; Structure; Relationships; Inferred function; Drug targets|
|Official Citation:||Bronwyn E. Campbell, Peter R. Boag, Andreas Hofmann, Cinzia Cantacessi, Conan K. Wang, Paul Taylor, Min Hu, Zia-ud-Din Sindhu, Alex Loukas, Paul W. Sternberg, Robin B. Gasser, Atypical (RIO) protein kinases from Haemonchus contortus -- Promise as new targets for nematocidal drugs, Biotechnology Advances, Volume 29, Issue 3, May-June 2011, Pages 338-350, ISSN 0734-9750, DOI: 10.1016/j.biotechadv.2011.01.006. (http://www.sciencedirect.com/science/article/B6T4X-520TJPM-2/2/fe68b1674a0e9b1f3b20617fc9a93cf9)|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Ruth Sustaita|
|Deposited On:||18 May 2011 18:17|
|Last Modified:||18 May 2011 18:17|
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