Wold, Barbara and Mortazavi, Ali and Williams, Brian and Marinov, Georgi and Trout, Diane and King, Brandon and McCue, Kenneth and Kirilusha, Anthony and DeSalvo, Gilberto and Fisher-Aylor, Katherine and Amrhein, Henry and Vielmetter, Jost and Pepke, Shirley (2011) A User's Guide to the Encyclopedia of DNA Elements (ENCODE). PLoS Biology, 9 (4). Art. No. e1001046. ISSN 1544-9173 http://resolver.caltech.edu/CaltechAUTHORS:20110520-094733599
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Abstract
The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results are made available through a freely accessible database. Here we provide an overview of the project and the resources it is generating and illustrate the application of ENCODE data to interpret the human genome.
| Item Type: | Article | ||||||
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| Additional Information: | © 2011 The ENCODE Project Consortium. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Received September 23, 2010; Accepted March 10, 2011; Published April 19, 2011. Academic Editor: Peter B. Becker, Adolf Butenandt Institute, Germany. Funding: Funded by the National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. The role of the NIH Project Management Group in the preparation of this paper was limited to coordination and scientific management of the ENCODE Consortium. We thank Judy R. Wexler and Julia Zhang at the National Human Genome Research Institute for their support in administering the ENCODE Consortium, additional members of our laboratories and institutions who have contributed to the experimental and analytical components of this project, and J. D. Frey for assistance in preparing the figures. | ||||||
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| Record Number: | CaltechAUTHORS:20110520-094733599 | ||||||
| Persistent URL: | http://resolver.caltech.edu/CaltechAUTHORS:20110520-094733599 | ||||||
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| Official Citation: | The ENCODE Project Consortium (2011) A User’s Guide to the Encyclopedia of DNA Elements (ENCODE). PLoS Biol 9(4): e1001046. doi:10.1371/ journal.pbio.1001046 | ||||||
| Usage Policy: | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | ||||||
| ID Code: | 23745 | ||||||
| Collection: | CaltechAUTHORS | ||||||
| Deposited By: | Tony Diaz | ||||||
| Deposited On: | 23 Jun 2011 23:28 | ||||||
| Last Modified: | 26 Dec 2012 13:15 |
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