Garcia, Hernan G. and Kondev, Jane and Orme, Nigel and Theriot, Julie A. and Phillips, Rob (2011) Thermodynamics of Biological Processes. In: Biothermodynamics. Part D. Methods in Enzymology (492). Elsevier , Amsterdam, pp. 27-59. ISBN 9780123860033 http://resolver.caltech.edu/CaltechAUTHORS:20110531-101647091
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There is a long and rich tradition of using ideas from both equilibrium thermodynamics and its microscopic partner theory of equilibrium statistical mechanics. In this chapter, we provide some background on the origins of the seemingly unreasonable effectiveness of ideas from both thermodynamics and statistical mechanics in biology. After making a description of these foundational issues, we turn to a series of case studies primarily focused on binding that are intended to illustrate the broad biological reach of equilibrium thinking in biology. These case studies include ligand-gated ion channels, thermodynamic models of transcription, and recent applications to the problem of bacterial chemotaxis. As part of the description of these case studies, we explore a number of different uses of the famed Monod–Wyman–Changeux (MWC) model as a generic tool for providing a mathematical characterization of two-state systems. These case studies should provide a template for tailoring equilibrium ideas to other problems of biological interest.
|Item Type:||Book Section|
|Additional Information:||© 2011 Elsevier Inc. Available online 17 February 2011. We are grateful to a number of people for giving us guidance in thinking about this problem and/or providing data: Tom Kuhlman, Terry Hwa, Ulrich Gerland, Leonid Mirny, Henry Lester, Doug Rees, and Dennis Dougherty. H. G. and R. P. are also extremely grateful to the NIH for support through the NIH Director’s Pioneer Award (DP1 OD000217), RO1 GM085286, and RO1 GM085286-01S. J. K. acknowledges the support of the National Science Foundation through grant DMR-0706458. J. A. T. was supported by the National Institutes of Health and the Howard Hughes Medical Institute.|
|Official Citation:||Hernan G. Garcia, Jane Kondev, Nigel Orme, Julie A. Theriot, Rob Phillips, Thermodynamics of Biological Processes, In: Michael L. Johnson, Jo M. Holt and Gary K. Ackers, Editor(s), Methods in Enzymology, Academic Press, 2011, Volume 492, Biothermodynamics, Part D, Pages 27-59, ISSN 0076-6879, ISBN 9780123860033, DOI: 10.1016/B978-0-12-381268-1.00014-8. (http://www.sciencedirect.com/science/article/pii/B9780123812681000148)|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Ruth Sustaita|
|Deposited On:||31 May 2011 18:44|
|Last Modified:||31 May 2011 18:44|
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