Hochheiser, Harry and Aronow, Bruce J. and Artinger, Kristin and Beaty, Terri H. and Brinkley, James F. and Chai, Yang and Clouthier, David and Cunningham, Michael L. and Dixon, Michael and Donahue, Leah Rae and Fraser, Scott E. and Hallgrimsson, Benedik and Iwata, Junichi and Klein, Ophir and Marazita, Mary L. and Murray, Jeffrey C. and Murray, Stephen and de Villena, Fernando Pardo-Manuel and Postlethwait, John and Potter, Steven and Shapiro, Linda and Spritz, Richard and Visel, Axel and Weinberg, Seth M. and Trainor, Paul A. (2011) The FaceBase Consortium: A comprehensive program to facilitate craniofacial research. Developmental Biology, 355 (2). pp. 175-182. ISSN 0012-1606 http://resolver.caltech.edu/CaltechAUTHORS:20110718-100407556
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The FaceBase Consortium consists of ten interlinked research and technology projects whose goal is to generate craniofacial research data and technology for use by the research community through a central data management and integrated bioinformatics hub. Funded by the National Institute of Dental and Craniofacial Research (NIDCR) and currently focused on studying the development of the middle region of the face, the Consortium will produce comprehensive datasets of global gene expression patterns, regulatory elements and sequencing; will generate anatomical and molecular atlases; will provide human normative facial data and other phenotypes; conduct follow up studies of a completed genome-wide association study; generate independent data on the genetics of craniofacial development, build repositories of animal models and of human samples and data for community access and analysis; and will develop software tools and animal models for analyzing and functionally testing and integrating these data. The FaceBase website (http://www.facebase.org) will serve as a web home for these efforts, providing interactive tools for exploring these datasets, together with discussion forums and other services to support and foster collaboration within the craniofacial research community.
|Additional Information:||© 2011 Elsevier Inc. Received 25 January 2011; revised 23 February 2011; accepted 24 February 2011. Available online 31 March 2011. The FaceBase Consortium thanks the many investigators and staff members for working collaboratively and untiringly toward fulfilling the goals of the program. In particular,we appreciate the vision and support of Dr. Lawrence A. Tabak, former Director of the National Institute of Dental and Craniofacial Research (NIDCR), in enabling this effort. We thank the NIDCR Program Staff for their advice in implementing FaceBase and suggestions for this manuscript (Program Official: Steven Scholnick; Project Scientists: Emily Harris, Nadya Lumelsky, Lillian Shum). We are very grateful to Carolyn Randolph for editorial assistance inpreparing this paper. Projects comprising the FaceBase Consortium are supported by grants from the NIDCR, U01-DE20049 (S.S.P., B.A., P.A.T), U01-DE20050 (L.S., M.L.C., J.F.B), U01-DE20052 (L.R.B.D., S.A.M.), U01-DE20054 (R.A.S.), U01-DE020057 (J.C.M., M.L.M., H.H. M.D.), U01-DE20060 (A.V.), U01-DE20063 (S.E.F.), U01-DE20065 (Y.C., J.I.), U01-DE20073 (T.H.B.), U01-DE20076 (D.E.C., K.B.A., J.H.P.) and U01-DE20078 (S.M.W., M.L.M. M.L.C).|
|Subject Keywords:||Craniofacial development; Cleft lip and palate; Human genetics; Animal models; Database; Morphometrics|
|Official Citation:||Harry Hochheiser, Bruce J. Aronow, Kristin Artinger, Terri H. Beaty, James F. Brinkley, Yang Chai, David Clouthier, Michael L. Cunningham, Michael Dixon, Leah Rae Donahue, Scott E. Fraser, Benedikt Hallgrimsson, Junichi Iwata, Ophir Klein, Mary L. Marazita, Jeffrey C. Murray, Stephen Murray, Fernando Pardo-Manuel de Villena, John Postlethwait, Steven Potter, Linda Shapiro, Richard Spritz, Axel Visel, Seth M. Weinberg, Paul A. Trainor, The FaceBase Consortium: A comprehensive program to facilitate craniofacial research, Developmental Biology, Volume 355, Issue 2, 15 July 2011, Pages 175-182, ISSN 0012-1606, DOI: 10.1016/j.ydbio.2011.02.033. (http://www.sciencedirect.com/science/article/pii/S0012160611001965)|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Ruth Sustaita|
|Deposited On:||18 Jul 2011 17:45|
|Last Modified:||18 Jul 2011 17:45|
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