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Evaluation of isovolumic relaxation phase in the process of ventricular remodeling following myocardial infarction

Kheradvar, A. and Gorman, R. C. and Gorman, J. H., III and Zeeshan, A. and Gharib, M. (2004) Evaluation of isovolumic relaxation phase in the process of ventricular remodeling following myocardial infarction. In: EMBC 2004 : 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Proceedings of Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE , Piscataway, NJ, pp. 3654-3657. ISBN 0-7803-8439-3 http://resolver.caltech.edu/CaltechAUTHORS:20110822-140411786

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Abstract

The course of cardiac remodeling after an acute cardiac MI, might affect the orientation of the cardiac muscle fibers as well as their contraction behavior. This may result in alteration of the untwisting during isovolumic relaxation phase, which might have effects on rapid early filling phase. In the present article, the variation of the time constant of isovolumic pressure drop (τ) has been studied during the course of cardiac remodeling after different types of induced myocardial infarction (MI) in sheep. The results for each group show different patterns of change in τ. The normalized τ curve in all three groups of anteroapical, anterobasal and posterobasal MI group show a rise 30 minutes after infarction. Two weeks later, the pressure drop constants decline to a lower level than baseline and by eight weeks after infarction, the time constant reached around the baseline level.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1109/IEMBS.2004.1404027 DOIUNSPECIFIED
http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=1404027PublisherUNSPECIFIED
Additional Information:© 2004 IEEE. Issue Date: 1-5 Sept. 2004. Date of Current Version: 14 March 2005.
Subject Keywords:isovolumic relaxation; pressure drop time constant; twisting; ventricular remodeling
Record Number:CaltechAUTHORS:20110822-140411786
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20110822-140411786
Official Citation:Kheradvar, A.; Gorman, R.C.; Gorman, J.H., III; Zeeshan, A.; Gharib, M.; , "Evaluation of Isovolumic Relaxation Phase in the Process of Ventricular Remodeling following Myocardial Infarction," Engineering in Medicine and Biology Society, 2004. IEMBS '04. 26th Annual International Conference of the IEEE , vol.2, no., pp. 3654- 3657, 1-5 Sept. 2004 doi: 10.1109/IEMBS.2004.1404027 URL: http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=1404027&isnumber=30463
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:24981
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:22 Aug 2011 22:25
Last Modified:22 Aug 2011 22:25

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