Forouhar, A. S. and Hove, J. R. and Calvert, C. and Flores, J. and Jadvar, H. and Gharib, M. (2004) Electrocardiographic Characterization of Embryonic Zebrafish. In: EMBC 2004 : 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Proceedings of Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.26. IEEE , Piscataway, NJ, pp. 3615-3617. ISBN 0-7803-8439-3 http://resolver.caltech.edu/CaltechAUTHORS:20110823-085037968
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The zebrafish (Danio rerio) has emerged as one of the primary experimental models of developmental cardiovascular research. Recent progress in flow visualization techniques along with the existing genetic map of the species has made zebrafish amenable to a variety of experiments relating cardiac developmental structure and function. One essential tool in establishing the proper functioning of the heart is the electrocardiogram (ECG). This study presents a methodology whereby the ECGs of embryonic zebrafish could be used in assessing the electrophysiological consequences of genetically-, mechanically-, or pharmacokinetically-induced cardiac perturbations. Five day post-fertilization (dpf) embryos produced repeating bimodal ECGs with clearly distinguished atrial (P) and ventricular (R) depolarization waves. P-R intervals along with P-P intervals are cited.
|Item Type:||Book Section|
|Additional Information:||© 2004 IEEE. Issue Date: 1-5 Sept. 2004. Date of Current Version: 14 March 2005.|
|Subject Keywords:||Zebrafish, heart, electrophysiology, ECG|
|Official Citation:||Forouhar, A.S.; Hove, J.R.; Calvert, C.; Flores, J.; Jadvar, H.; Gharib, M.; , "Electrocardiographic Characterization of Embryonic Zebrafish," Engineering in Medicine and Biology Society, 2004. IEMBS '04. 26th Annual International Conference of the IEEE , vol.2, no., pp. 3615- 3617, 1-5 Sept. 2004 doi: 10.1109/IEMBS.2004.1404016 URL: http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=1404016&isnumber=30463|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||23 Aug 2011 16:38|
|Last Modified:||23 Aug 2011 16:38|
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