Zheng, Siyang and Tai, Yu-Chong and Kasdan, Harvey (2005) A Micro Device for Separation of Erythrocytes and Leukocytes in Human Blood. In: 2005 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Proceedings of Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE , Piscataway, NJ, pp. 1024-1027. ISBN 0-7803-8740-6 http://resolver.caltech.edu/CaltechAUTHORS:20110829-095853628
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We report a MEMS device for continuous and binary separation of leukocytes (white blood cells, WBCs) and erythrocytes (red blood cells, RBCs) by their sizes. The system consists of PDMS cylindrical pillars inside fluidic chamber on glass slides. A 420 µm lateral separation was achieved for 5 µm and 10 µm beads. The critical particle size for separation was successful predicted by simulation and experimentally determined by calibration with polystyrene beads. The separation function (lateral displacement versus particle size) was also measured experimentally. Diluted whole blood and blood fraction of concentrated leukocytes were tested with the devices with erythrocyte to leukocyte ratio in agreement with blood count results. Experiments with fluorescent labeled leukocytes confirm the separation of leukocytes from erythrocytes and measured the separation efficiency.
|Item Type:||Book Section|
|Additional Information:||© 2005 IEEE. Issue Date: 17-18 Jan. 2006. Date of Current Version: 10 April 2006. This work is supported by NASA through National Space Biomedical Research Institute (NSBRI). The cooperative agreement number is NCC 9-58-317.|
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|Official Citation:||Siyang Zheng; Yu-Chong Tai; Kasdan, H.; , "A Micro Device for Separation of Erythrocytes and Leukocytes in Human Blood," Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the , vol., no., pp.1024-1027, 17-18 Jan. 2006 doi: 10.1109/IEMBS.2005.1616592 URL: http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=1616592&isnumber=33900|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||31 Aug 2011 21:14|
|Last Modified:||31 Aug 2011 21:14|
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