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Process of Infection with Bacteriophage {varphi}X174 XXXIII. Templates for the Synthesis of Single-Stranded Deoxyribonucleic Acid

Funk, Fred and Sinsheimer, Robert L. (1970) Process of Infection with Bacteriophage {varphi}X174 XXXIII. Templates for the Synthesis of Single-Stranded Deoxyribonucleic Acid. Journal of Virology, 5 (3). pp. 282-288. ISSN 0022-538X. http://resolver.caltech.edu/CaltechAUTHORS:FUNjvir70a

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Abstract

The origin of the templates for the synthesis of {varphi}X174 progeny single-stranded deoxyribonucleic acid was studied by means of the mutagenic activity associated with the decay of incorporated 3H-labeled 5-cytosine. The results indicate that the single-strand synthesis occurs in an asymmetric semiconservative manner using as template the complementary strands of the pool of replicative from molecules accumulated during the eclipse period. These complementary strands are repeatedly used as templates, and there is no detectable preferential use of complementary strand templates made early in the eclipse versus those made late.


Item Type:Article
Additional Information:Copyright © 1970 American Society for Microbiology. Received for publication 6 October 1969 This research was supported in part by Public Health Service grant GM13554 from the U.S. Public Health Service.
Record Number:CaltechAUTHORS:FUNjvir70a
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:FUNjvir70a
Alternative URL:http://jvi.asm.org/cgi/content/abstract/5/3/282
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:2538
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:07 Apr 2006
Last Modified:26 Dec 2012 08:49

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