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Evaluation of the energetic contribution of an ionic network to beta-sheet stability

Lassila, Kirsten S. and Datta, Deepshikha and Mayo, Stephen L. (2002) Evaluation of the energetic contribution of an ionic network to beta-sheet stability. Protein Science, 11 (3). pp. 688-690. ISSN 0961-8368. http://resolver.caltech.edu/CaltechAUTHORS:20110928-153816383

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Abstract

We have evaluated the interaction energy of a three-residue ionic network constructed on the β-sheet surface of protein G using double mutant cycles. Although the two individual ion pairs were each stabilizing by ~0.6 kcal/mol, the excess gain in stability for the triad was small (0.06 kcal/mol).


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1110/ps.23502DOIUNSPECIFIED
http://onlinelibrary.wiley.com/doi/10.1110/ps.23502/abstractPublisherUNSPECIFIED
Contact Email Address:steve@mayo.caltech.edu
Additional Information:© 2002 The Protein Society. Received June 19, 2001; Accepted November 30, 2001. Article first published online: 13 Apr. 2009.
Subject Keywords:Nerve Tissue Proteins; Amino Acids; Thermodynamics; Ions; Protein Structure: Secondary; Static Electricity; Kinetics; Models: Molecular; Mutation; Protein Binding; Protein Structure: Tertiary; β-Sheet; protein stability; protein design; electrostatics; side chain interactions
Record Number:CaltechAUTHORS:20110928-153816383
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20110928-153816383
Official Citation:Lassila, K. S., Datta, D. and Mayo, S. L. (2002), Evaluation of the energetic contribution of an ionic network to beta-sheet stability. Protein Science, 11: 688–690. doi: 10.1110/ps.23502
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:25478
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:29 Sep 2011 16:24
Last Modified:23 Aug 2016 10:05

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