O'Connell, Ryan M. and Zhao, Jimmy L. and Rao, Dinesh S. (2011) MicroRNA function in myeloid biology. Blood, 118 (11). pp. 2960-2969. ISSN 0006-4971 http://resolver.caltech.edu/CaltechAUTHORS:20111003-104440016
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The past 5 years have seen an explosion of knowledge about miRNAs and their roles in hematopoiesis, cancer, and other diseases. In myeloid development, there is a growing appreciation for both the importance of particular miRNAs and the unique features of myelopoiesis that are being uncovered by experimental manipulation of miRNAs. Here, we review in detail the roles played by 4 miRNAs, miR-125, miR-146, miR-155, and miR-223 in myeloid development and activation, and correlate these roles with their dysregulation in disease. All 4 miRNAs demonstrate effects on myelopoiesis, and their loss of function or overexpression leads to pathologic phenotypes in the myeloid lineage. We review their functions at distinct points in development, their targets, and the regulatory networks that they are embedded into in the myeloid lineage.
|Additional Information:||© 2011 by The American Society of Hematology. Submitted March 16, 2011; accepted June 17, 2011. Prepublished online as Blood First Edition paper, July 1, 2011. The authors thank David Baltimore for helpful discussions over the years regarding miRNA biology and pathology. D.S.R. was supported by the National Institutes of Health (career development award 5K08CA133521). R.M.O. was supported by the National Heart, Lung, and Blood Institute (award K99HL102228). J.L.Z. was supported by the National Institutes of Health (joint University of California Los Angeles/Caltech Medical Scientist Training Grant). Contribution: D.S.R. planned and reviewed all sections of the review; and all authors wrote sections of the review and generated the figures. Conflict-of-interest disclosure: The authors declare no competing financial interests. The current affiliation for R.M.O. is Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT.|
|Official Citation:||Ryan M. O'Connell, Jimmy L. Zhao, and Dinesh S. Rao MicroRNA function in myeloid biology Blood 2011 118:2960-2969; published ahead of print July 1, 2011, doi:10.1182/blood-2011-03-291971|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Ruth Sustaita|
|Deposited On:||03 Oct 2011 18:15|
|Last Modified:||03 Oct 2011 18:15|
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