Yin, Peng and Hariadi, Rizal F. and Sahu, Sudheer and Choi, Harry M. T. and Park, Sung Ha and LaBean, Thomas H. and Reif, John H. (2008) Programming DNA Tube Circumferences. Science, 321 (5890). pp. 824-826. ISSN 0036-8075 http://resolver.caltech.edu/CaltechAUTHORS:20111020-104503059
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Synthesizing molecular tubes with monodisperse, programmable circumferences is an important goal shared by nanotechnology, materials science, and supermolecular chemistry. We program molecular tube circumferences by specifying the complementarity relationships between modular domains in a 42-base single-stranded DNA motif. Single-step annealing results in the self-assembly of long tubes displaying monodisperse circumferences of 4, 5, 6, 7, 8, 10, or 20 DNA helices.
|Additional Information:||© 2008 American Association for the Advancement of Science. Received for publication 4 March 2008. Accepted for publication 16 June 2008. The authors thank E. Winfree at Caltech for generously hosting the majority part of this work in his lab. For inspiring discussions, the authors thank E. Winfree, P. W. K. Rothemund, R. Schulman, V. A. Beck, J. R. Vieregg, R. D. Barish, B. Yurke, D. Y. Zhang, N. A. Pierce, S. Hamada, M. Bockrath, H. Maune, Y. Huang, C. R. Calvert, N. L. Dabby, and J. Kim. The authors are also grateful to N. A. Pierce at Caltech and J. Liu at Duke for facility support, to the Pierce group for the use of the unpublished DNA sequence design component and DNA structure illustration component of the NUPACK server (www.nupack.org), and to B. Walters for technical assistance. The fluorescence microscope was built by R.F.H. and B. Yurke. There is a patent pending on this work. This work is supported by the Center for Biological Circuit Design at Caltech, NSF grants CCF-0523555 and CCF-0432038 to J.H.R., NSF grant CBET-0508284 to T.H.L., NSF grants 0622254 and 0432193 to E. Winfree, and NSF grant 0506468 to N. A. Pierce.|
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|Deposited By:||Tony Diaz|
|Deposited On:||24 Oct 2011 22:16|
|Last Modified:||26 Dec 2012 14:17|
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