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Selectivity of pyramidal cells and interneurons in the human medial temporal lobe

Ison, Matias J. and Mormann, Florian and Cerf, Moran and Koch, Christof and Fried, Itzhak and Quiroga, Rodrigo Quian (2011) Selectivity of pyramidal cells and interneurons in the human medial temporal lobe. Journal of Neurophysiology, 106 (4). pp. 1713-1721. ISSN 0022-3077. PMCID PMC3191845. http://resolver.caltech.edu/CaltechAUTHORS:20111115-093608580

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Abstract

Neurons in the medial temporal lobe (MTL) respond selectively to pictures of specific individuals, objects, and places. However, the underlying mechanisms leading to such degree of stimulus selectivity are largely unknown. A necessary step to move forward in this direction involves the identification and characterization of the different neuron types present in MTL circuitry. We show that putative principal cells recorded in vivo from the human MTL are more selective than putative interneurons. Furthermore, we report that putative hippocampal pyramidal cells exhibit the highest degree of selectivity within the MTL, reflecting the hierarchical processing of visual information. We interpret these differences in selectivity as a plausible mechanism for generating sparse responses.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1152/jn.00576.2010DOIArticle
http://jn.physiology.org/content/106/4/1713PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191845/PubMed CentralArticle
ORCID:
AuthorORCID
Mormann, Florian0000-0003-1305-8028
Koch, Christof0000-0001-6482-8067
Additional Information:© 2011 American Physiological Society. Submitted 28 June 2010; accepted in final form 27 June 2011. We are grateful to all patients for their participation and Tony Fields, Eric Behnke, Anna Postolova, Neel Parikshak, and Vanessa Isiaka for technical assistance. This work was supported by grants from the National Institute of Neurological Disorders and Stroke, the Engineering and Physical Sciences Research Council, Medical Research Council, the National Institute of Mental Health, the Defense Advanced Research Projects Agency, the World Class University Program Through the National Research Foundation of Korea funded by the Ministry of Education, Science, and Technology (R31-10008, to C. Koch), and the Mathers Foundation.
Group:KLAB, Koch Laboratory
Funders:
Funding AgencyGrant Number
National Institute of Neurological Disorders and Stroke (NINDS)UNSPECIFIED
Engineering and Physical Sciences Research Council (EPSRC)UNSPECIFIED
Medical Research Council (UK)UNSPECIFIED
National Institute of Mental Health (NIMH)UNSPECIFIED
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Ministry of Education, Science, and Technology (Korea)R31-10008
Mathers FoundationUNSPECIFIED
NIHUNSPECIFIED
Subject Keywords:sparse coding; hippocampus; memory formation; hierarchical processing; winner-take-all; epilepsy
PubMed Central ID:PMC3191845
Record Number:CaltechAUTHORS:20111115-093608580
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20111115-093608580
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:27778
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:15 Nov 2011 20:55
Last Modified:08 Feb 2017 17:04

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