Yang, Changhuei and McGuckin, Laura E. L. and Simon, John D. and Choma, Michael A. and Applegate, Brian E. and Izatt, Joseph A. (2004) Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent. Optics Letters, 29 (17). pp. 2016-2018. ISSN 0146-9592. PMCID PMC1283115. http://resolver.caltech.edu/CaltechAUTHORS:YANol04
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We report a new molecular contrast optical coherence tomography (MCOCT) implementation that profiles the contrast agent distribution in a sample by measuring the agent's spectral differential absorption. The method, spectra triangulation MCOCT, can effectively suppress contributions from spectrally dependent scatterings from the sample without a priori knowledge of the scattering properties. We demonstrate molecular imaging with this new MCOCT modality by mapping the distribution of indocyanine green, a FDA-approved infrared red dye, within a stage 54 Xenopus laevis.
|Additional Information:||© 2004 Optical Society of America. Received April 2, 2004. We thank several colleagues for suggesting the use of ICG as a MCOCT contrast agent, most notably Hubert van den Bergh. This research was supported by National Institutes of Health grant EB000243.|
|Subject Keywords:||Optical coherence tomography; Medical and biological imaging|
|PubMed Central ID:||PMC1283115|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Archive Administrator|
|Deposited On:||28 Apr 2006|
|Last Modified:||13 Mar 2017 22:04|
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