Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent

Yang, Changhuei and McGuckin, Laura E. L. and Simon, John D. and Choma, Michael A. and Applegate, Brian E. and Izatt, Joseph A. (2004) Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent. Optics Letters, 29 (17). pp. 2016-2018. ISSN 0146-9592 http://resolver.caltech.edu/CaltechAUTHORS:YANol04

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Abstract

We report a new molecular contrast optical coherence tomography (MCOCT) implementation that profiles the contrast agent distribution in a sample by measuring the agent's spectral differential absorption. The method, spectra triangulation MCOCT, can effectively suppress contributions from spectrally dependent scatterings from the sample without a priori knowledge of the scattering properties. We demonstrate molecular imaging with this new MCOCT modality by mapping the distribution of indocyanine green, a FDA-approved infrared red dye, within a stage 54 Xenopus laevis.

Item Type:	Article
Additional Information:	© 2004 Optical Society of America Received April 2, 2004 We thank several colleagues for suggesting the use of ICG as a MCOCT contrast agent, most notably Hubert van den Bergh. This research was supported by National Institutes of Health grant EB000243.
Subject Keywords:	Optical coherence tomography; Medical and biological imaging
Record Number:	CaltechAUTHORS:YANol04
Persistent URL:	http://resolver.caltech.edu/CaltechAUTHORS:YANol04
Alternative URL:	http://www.opticsinfobase.org/abstract.cfm?URI=ol-29-17-2016
Usage Policy:	No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:	2806
Collection:	CaltechAUTHORS
Deposited By:	Archive Administrator
Deposited On:	28 Apr 2006
Last Modified:	26 Dec 2012 08:51

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