Boes, Aaron D. and Mehta, Sonya and Rudrauf, David and Van Der Plas, Ellen and Grabowski, Thomas and Adolphs, Ralph and Nopoulos, Peg (2011) Changes in cortical morphology resulting from long-term amygdala damage. Social Cognitive and Affective Neuroscience, 6 (4). ISSN 1749-5016 http://resolver.caltech.edu/CaltechAUTHORS:20111219-110244010
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The amygdala's contribution to emotion, cognition and behavior depends on its interactions with subcortical and cortical regions. Amygdala lesions result in altered functional activity in connected regions, but it is not known whether there might be long-term structural sequelae as well. We hypothesized that developmental bilateral amygdala lesions would be associated with specific gray matter morphometric abnormalities in the ventromedial prefrontal cortex (vmPFC), anterior cingulate cortex (ACC) and the ventral visual stream. We conducted regions of interest and vertex-based analyses of structural MRI data acquired in two patients with long-standing focal bilateral amygdala lesions (S.M. and A.P.), compared to gender- and age-matched healthy comparison subjects. Both patients showed significant proportional increases in gray matter volume of the vmPFC. Cortical thickness was increased in the vmPFC and ACC and decreased in the ventral visual stream. There were no morphometric changes in dorsolateral prefrontal cortex or dorsal visual stream cortices. These findings support the hypothesis that cortical regions strongly connected with the amygdala undergo morphometric changes with long-standing amygdala damage. This is the first evidence in humans of the remote alteration of brain morphology in association with amygdala lesions, and will help in interpreting the structural and functional consequences of amygdala pathology in neuropsychiatric disorders.
|Additional Information:||© 2011 The Author. Published by Oxford University Press. Received November 7, 2010. Accepted June 22, 2011. Advance Access published September 6, 2011. This research was supported in part by the following grants: NIH NS 019632. The authors thank Douglas Langbehn for his guidance in the statistical analysis. The authors also thank Hans Johnson, Greg Harris and Nick Jones for technical support.|
|Subject Keywords:||amygdala; lesions; morphometry; plasticity; prefrontal cortex; ventromedial|
|Official Citation:||Aaron D. Boes, Sonya Mehta, David Rudrauf, Ellen Van Der Plas, Thomas Grabowski, Ralph Adolphs, and Peg Nopoulos Changes in cortical morphology resulting from long-term amygdala damage Soc Cogn Affect Neurosci first published online September 6, 2011 doi:10.1093/scan/nsr047|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Ruth Sustaita|
|Deposited On:||19 Dec 2011 19:44|
|Last Modified:||19 Dec 2011 19:44|
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