Arnone, Maria I. and Davidson, Eric H. (1997) The hardwiring of development: Organization and function of genomic regulatory systems. Development, 124 (10). pp. 1851-1864. ISSN 0950-1991. http://resolver.caltech.edu/CaltechAUTHORS:20120118-111631985
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The gene regulatory apparatus that directs development is encoded in the DNA, in the form of organized arrays of transcription factor target sites. Genes are regulated by interactions with multiple transcription factors and the target sites for the transcription factors required for the control of each gene constitute its cis-regulatory system. These systems are remarkably complex. Their hardwired internal organization enables them to behave as genomic information processing systems. Developmental gene regulatory networks consist of the cis-regulatory systems of all the relevant genes and the regulatory linkages amongst them. Though there is yet little explicit information, some general properties of genomic regulatory networks have become apparent. The key to understanding how genomic regulatory networks are organized, and how they work, lies in experimental analysis of cis-regulatory systems at all levels of the regulatory network.
|Additional Information:||© 1997 The Company of Biologists Limited. Accepted 14 March 1997. The authors are grateful to reviewers of drafts of this manuscript, for their extremely helpful criticisms and comments, and above all, their perspicacity. These reviewers were Professor Barbara Wold, Professor Ellen Rothenberg and Dr R. Andrew Cameron of this Institute; Professor Lee Hood of the University of Washington; Professor Nadia Rosenthal of Harvard Medical School; Professor Eric Olson of the University of Texas Southwestern Medical Center; Dr Carmen Kirchhamer of Harvard University and Professor James W. Posakony University of California, San Diego. This work was supported by the Stowers Institute for Medical Research and by the National Institute of Child Health and Human Development.|
|Subject Keywords:||gene regulation; cis-regulatory element; regulatory module; transcription factor; gene network|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||18 Jan 2012 19:56|
|Last Modified:||26 Dec 2012 14:42|
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