Elaagouby, Abdelkrim and Gervais, Rémi (1996) Induction of a Calcium-dependent Long-term Enhancement of Excitability in the Rat Olfactory Bulb. Chemical Senses, 21 (2). pp. 159-168. ISSN 0379-864X http://resolver.caltech.edu/CaltechAUTHORS:20120131-133456238
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We have investigated whether a transient increase in extracellular calcium concentration is able to induce long-term modification of neuronal excitability in the olfactory bulb. High-calcium artificial cerebrospinal fluid containing picrotoxin (Ca-PTX solution) was applied locally near the mitral cell layer through a push-pull device for 10 min in anaesthetized rats. Changes in the neuronal excitability were monitored through electrically-evoked field potentials. Application of the Ca-PTX solution induced a rapid increase in the granule cell response amplitude, whereas mitral/tufted cells response amplitude increased more progressively and reached its maximum within a few hours. The increase in mitral/tufted cells response and granule cells response reached between 30 and 100% in experiments which lasted for 4–8 h. Pre-application of amino-phosphonovalerate (NMDA receptor blocker) potently reduced both short- and long-term enhancement produced by the Ca-PTX solution. Neither application of the high calcium solution alone nor the picrotoxin solution alone induced long-term changes. The results point out the possible importance of Ca^(2+) and NMDA receptors in persistent forms of olfactory bulb plasticity. Relevance of this phenomenon in normal olfactory bulb physiology remains to be examined.
|Additional Information:||© 1996 Oxford University Press. Received on March 30, 1995; accepted on January 5, 1996. The authors thank Pascal Chabaud and Philippe Litaudon for their help in the preparation of illustrations and an anonymous referee for his constructive suggestions.|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||21 Mar 2012 20:57|
|Last Modified:||21 Mar 2012 20:57|
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