Elbert, Donald L. and Hubbell, Jeflrey A. (1996) Surface Treatments of Polymers for Biocompatibility. Annual Review of Materials Science, 26 . pp. 365-394. ISSN 0084-6600 http://resolver.caltech.edu/CaltechAUTHORS:20120202-134244489
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Biological recognition mediates cell and tissue interactions with biomaterials, be the materials employed in a biotechnical environment in vitro or a biomedical environment in vivo. These interactions are typically mediated by proteins that have adsorbed to the biomaterial surface. The principles of protein adsorption and biological recognition are described. Polymer surface modifications to reduce protein adsorption upon biomaterial surfaces are summarized, as are modifications to enhance the irreversible adsorption of proteins. Using these approaches, it may be possible to reduce the extent to which the biomaterial surface and the protein-biomaterial surface are recognized by cells and tissues. Polymer surface modifications to incorporate oligopeptide-, saccharide-, and oligosaccharide-based receptor-binding sequences are described to enable direct binding of cells with the polymer surface. With use of these approaches, it is possible to endow an entirely synthetic material with the biological recognition characteristics of biological macromolecules.
|Additional Information:||© 1996 by Annual Reviews Inc.|
|Subject Keywords:||biomaterial; peptide; saccharide; hydrogel; poly(ethylene glycol)|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||24 Feb 2012 18:43|
|Last Modified:||24 Feb 2012 18:43|
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