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Subunit Stoichiometry of a Heteromultimeric G protein-coupled Inward-rectifier K^+ Channel

Silverman, Scott K. and Lester, Henry A. and Dougherty, Dennis A. (1996) Subunit Stoichiometry of a Heteromultimeric G protein-coupled Inward-rectifier K^+ Channel. Journal of Biological Chemistry, 271 (48). pp. 30524-30528. ISSN 0021-9258.

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We investigated the stoichiometry of the heteromultimeric G protein-coupled inward-recitfier K^+ channel (GIRK) formed from GIRK1 and GIRK4 subunits. Multimeric GIRK constructs with several concatenated channel subunits were expressed in Xenopus oocytes. Coexpression of various trimeric constructs with different monomers clearly showed that the functional channel has stoichiometry (GIRK1)_2(GIRK4)_2. Efforts to establish a preferred arrangement of subunits around the channel pore suggest that more than one arrangement may be viable.

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Additional Information:© 1996 by The American Society for Biochemistry and Molecular Biology, Inc. Received June 5, 1996. Revision received July 23, 1996. We thank Paulo Kofuji for many helpful discussions. This work was supported by National Institutes of Health Grants MH49176, GM29836, NS11756, and NS34407. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
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ID Code:29176
Deposited By: Tony Diaz
Deposited On:21 Mar 2012 20:53
Last Modified:26 Dec 2012 14:48

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