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The alphaviruses: gene expression, replication, and evolution

Strauss, James H. and Strauss, Ellen G. (1994) The alphaviruses: gene expression, replication, and evolution. Microbiological Reviews, 58 (3). pp. 491-562. ISSN 0146-0749. http://resolver.caltech.edu/CaltechAUTHORS:20120223-132820547

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Abstract

The alphaviruses are a genus of 26 enveloped viruses that cause disease in humans and domestic animals. Mosquitoes or other hematophagous arthropods serve as vectors for these viruses. The complete sequences of the +/- 11.7-kb plus-strand RNA genomes of eight alphaviruses have been determined, and partial sequences are known for several others; this has made possible evolutionary comparisons between different alphaviruses as well as comparisons of this group of viruses with other animal and plant viruses. Full-length cDNA clones from which infectious RNA can be recovered have been constructed for four alphaviruses; these clones have facilitated many molecular genetic studies as well as the development of these viruses as expression vectors. From these and studies involving biochemical approaches, many details of the replication cycle of the alphaviruses are known. The interactions of the viruses with host cells and host organisms have been exclusively studied, and the molecular basis of virulence and recovery from viral infection have been addressed in a large number of recent papers. The structure of the viruses has been determined to about 2.5 nm, making them the best-characterized enveloped virus to date. Because of the wealth of data that has appeared, these viruses represent a well-characterized system that tell us much about the evolution of RNA viruses, their replication, and their interactions with their hosts. This review summarizes our current knowledge of this group of viruses.


Item Type:Article
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC372977/PubMed Central IDUNSPECIFIED
Additional Information:© 1994 American Society for Microbiology. We are grateful to our many colleagues who shared ideas with us and who furnished us with material before publication. We are particularly grateful to R. H. Cheng, R. J. Kuhn, N. H. Olson, M. G. Rossmann, H.-K. Choi, and T. S. Baker for furnishing us with figures of RR virus structure prior to publication. Our work is supported by grants AI 10793 and Al 20612 from NIH and grant DMB-9104054 from NSF.
Funders:
Funding AgencyGrant Number
NIHAI 10793
NIHAl 20612
NSFDMB-9104054
Record Number:CaltechAUTHORS:20120223-132820547
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20120223-132820547
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ID Code:29442
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:23 Feb 2012 23:22
Last Modified:26 Dec 2012 14:52

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