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π, a Pre-B-Cell-Specific Enhancer Element in the Immunoglobulin Heavy-Chain Enhancer

Libermann, Towia A. and Baltimore, David (1993) π, a Pre-B-Cell-Specific Enhancer Element in the Immunoglobulin Heavy-Chain Enhancer. Molecular and Cellular Biology, 13 (10). pp. 5957-5969. ISSN 0270-7306. http://resolver.caltech.edu/CaltechAUTHORS:20120307-141507389

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Abstract

We have identified a new immunoglobulin heavy-chain enhancer element, designated π, between the µE2 and µE3 elements. The π enhancer element is transcriptionally active primarily during early stages of B-cell development but becomes virtually inactive during B-cell maturation at about the stage of immunoglobulin K light-chain gene rearrangement. Mutational analysis suggests that the π element is crucial for immunoglobulin heavy-chain enhancer activity at the pre-B-cell stage but is almost irrelevant for enhancer activity at the mature B-cell or plasma-cell stage. The activity of the π enhancer element correlates with the presence of an apparently pre-B-cell-specific protein-DNA complex. The similarity of the π site to recognition sequences for members of the ets gene family suggests that the protein(s) interacting with the π site most likely are ets-related transcription factors.


Item Type:Article
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http://dx.doi.org/10.1128/​MCB.13.10.5957DOIUNSPECIFIED
http://mcb.asm.org/content/13/10/5957PublisherUNSPECIFIED
Additional Information:© 1993 American Society for Microbiology. Received 19 April 1993. Returned for modification 20 May 1993. Accepted 30 June 1993. This work was supported by a fellowship from the Leukemia Society of America (to T.A.L.) and PHS grant GM 39458 (to D.B.). Much of this work was performed at the Whitehead Institute for Biomedical Research, Cambridge, Mass., and Department of Biology, Massachusetts Institute of Technology, Cambridge, Mass.
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Funding AgencyGrant Number
Leukemia Society of AmericaUNSPECIFIED
PHSGM 39458
Record Number:CaltechAUTHORS:20120307-141507389
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20120307-141507389
Official Citation:π, a pre-B-cell-specific enhancer element in the immunoglobulin heavy-chain enhancer. T A Libermann and D Baltimore Mol. Cell. Biol. October 1993 13:5957-5969; doi:10.1128/MCB.13.10.5957
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:29627
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:13 Mar 2012 15:25
Last Modified:13 Mar 2012 15:25

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