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Integration of biochemical signalling in spines

Kennedy, Mary B. and Beale, Holly C. and Carlisle, Holly J. and Washburn, Lorraine R. (2005) Integration of biochemical signalling in spines. Nature Reviews Neuroscience, 6 (6). pp. 423-434. ISSN 1471-003X.

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Short-term and long-term changes in the strength of synapses in neural networks underlie working memory and long-term memory storage in the brain. These changes are regulated by many biochemical signalling pathways in the postsynaptic spines of excitatory synapses. Recent findings about the roles and regulation of the small GTPases Ras, Rap and Rac in spines provide new insights into the coordination and cooperation of different pathways to effect synaptic plasticity. Here, we present an initial working representation of the interactions of five signalling cascades that are usually studied individually. We discuss their integrated function in the regulation of postsynaptic plasticity.

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Kennedy, Mary B.0000-0003-1369-0525
Additional Information:© 2005 Nature Publishing Group. This work was supported by grants from the National Institutes of Health to M.B.K., fellowships from the National Institutes of Health to H.J.C. and to the Division of Biology for support of H.C.B., and a fellowship from the John Douglas French Alzheimer’s Foundation to L.R.W. We thank E. Marcora of the Kennedy lab for valuable comments on the manuscript.
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John Douglas French Alzheimer’s FoundationUNSPECIFIED
Record Number:CaltechAUTHORS:20120424-145108832
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:30302
Deposited By: Melanie Stefan
Deposited On:24 Apr 2012 22:00
Last Modified:09 Apr 2015 23:26

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