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Interaction of ion channels and receptors with PDZ domain proteins.

Kornau, Hans-Christian and Seeburg, Peter H. and Kennedy, Mary B. (1997) Interaction of ion channels and receptors with PDZ domain proteins. Current Opinion in Neurobiology, 7 (3). pp. 368-373. ISSN 0959-4388. http://resolver.caltech.edu/CaltechAUTHORS:20120424-154222584

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Abstract

The complex anatomy of neurons demands a high degree of functional organization. Therefore, membrane receptors and ion channels are often localized to selected subcellular sites and coupled to specific signal transduction machineries. PDZ domains have come into focus as protein interaction modules that mediate the binding of a class of submembraneous proteins to membrane receptors and ion channels and thus subserve these organizational aspects. The structures of two PDZ domains have been resolved, which has led to a structural understanding of the specificity of interactions of various PDZ domains with their respective partners. The functional implications of PDZ domain interactions are now being addressed in vitro and in vivo.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/S0959-4388(97)80064-5DOIUNSPECIFIED
http://www.sciencedirect.com/science/article/pii/S0959438897800645PublisherUNSPECIFIED
Additional Information:© 1997 Current Biology Ltd. Available online 11 February 2002. The authors’ work is supported by U.S. Public Health Service grant NS-28710 to MB Kennedy and by Deutsche Forschungsgemeinschaft grant SFB317/B9 to PH Seeburg.
Funders:
Funding AgencyGrant Number
U.S. Public Health Service (USPHS)NS-28710
Deutsche Forschungsgemeinschaft (DFG)SFB317/B9
Record Number:CaltechAUTHORS:20120424-154222584
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20120424-154222584
Official Citation: Hans-Christian Kornau, Peter H Seeburg, Mary B Kennedy, Interaction of ion channels and receptors with PDZ domain proteins, Current Opinion in Neurobiology, Volume 7, Issue 3, June 1997, Pages 368-373, ISSN 0959-4388, 10.1016/S0959-4388(97)80064-5.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:30327
Collection:CaltechAUTHORS
Deposited By: Melanie Stefan
Deposited On:25 Apr 2012 14:47
Last Modified:25 Apr 2012 14:47

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