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Hippocampal Neurons Predisposed to Neurofibrillary Tangle Formation Are Enriched in Type II Calcium/Calmodulin-Dependent Protein Kinase

McKee, Ann C. and Kosik, Kenneth S. and Kennedy, Mary B. and Kowall, Neil W. (1990) Hippocampal Neurons Predisposed to Neurofibrillary Tangle Formation Are Enriched in Type II Calcium/Calmodulin-Dependent Protein Kinase. Journal of Neuropathology and Experimental Neurology, 49 (1). pp. 49-63. ISSN 0022-3069. http://resolver.caltech.edu/CaltechAUTHORS:20120424-154234958

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Abstract

The microtubule-associated phosphoprotein, tau, is an integral component of paired helical filaments in Alzheimer neurofibrillary tangles (NFT). The mechanism of NFT formation is unknown but aberrant phosphorylation of tau may be contributory. Calcium/calmodulin-dependent protein kinase type II (CaM kinase II), the most abundant kinase in the brain, phosphorylates tau in vitro. We found CaM kinase II immunoreactivity concentrated in human hippocampal pyramidal neurons of CA1 and the subiculum. In Alzheimer's disease (AD) staining intensity of CA1 and subicular neurons is strikingly increased despite NFT formation and neuronal depletion. Enhanced CaM kinase II activity, possibly a result of deafferentation, may contribute to phosphorylation of tau protein leading to NFT deposition and neuronal death in AD.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1097/00005072-199001000-00006 DOIUNSPECIFIED
Additional Information:© 1990 American Association of Neuropathologists, Inc. Received 20 September 1988; Accepted 27 June 1989. Supported in part by NIH grant AG05134 and AG06601, Massachusetts Alzheimer's Disease Research Center and NINDS Career Investigator Development Award (ACMcK) NS 01368-01. We thank Lawrence Cherkas for photographic assistance.
Funders:
Funding AgencyGrant Number
NIHAG05134
NIHAG06601
Massachusetts Alzheimer's Disease Research CenterUNSPECIFIED
NINDS Career Investigator Development Award NS 01368-01
Subject Keywords:Alzheimer's disease; Calcium/calmodulin-dependent kinase II; Hippocampus; Protein kinase; Tau protein
Record Number:CaltechAUTHORS:20120424-154234958
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20120424-154234958
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:30340
Collection:CaltechAUTHORS
Deposited By: Melanie Stefan
Deposited On:10 May 2012 22:12
Last Modified:10 May 2012 22:12

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