Kennedy, Mary B. (1989) Do activity-dependent changes in expression of regulatory proteins play a role in the progression of central nervous system neural degeneration? Annals of the New York Academy of Sciences, 568 . pp. 193-197. ISSN 0077-8923 http://resolver.caltech.edu/CaltechAUTHORS:20120424-154237552
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Cellular responses to the environment are initiated through membrane receptors that are activated by hormones or other extracellular agents. Activated receptors communicate to molecular machinery within the cell either by changing the flux of ions across the membrane or by altering the synthesis or degradation of second messengers such as CAMP, calcium ion, or diacylglycerol. One major mechanism through which these messengers control cell function is the activation of protein kinases. It seems increasingly clear that coordinated control over many cell processes at once is often exerted by networks of protein kinases, perhaps tailored specifically for each cell type. We have only begun to glimpse how these networks might be organized. Most current research is still aimed at the important goal of identifying and thoroughly characterizing the key regulatory proteins (often protein kinases) that mediate regulation by each second messenger in each specialized cell.
|Additional Information:||© 1989 New York Academy of Sciences. Article first published online: 17 Dec. 2006.|
|Official Citation:||KENNEDY, M. B. (1989), Do Activity-Dependent Changes in Expression of Regulatory Proteins Play a Role in the Progression of Central Nervous System Neural Degeneration?. Annals of the New York Academy of Sciences, 568: 193–197. doi: 10.1111/j.1749-6632.1989.tb12508.x|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Melanie Stefan|
|Deposited On:||25 Apr 2012 15:11|
|Last Modified:||25 Apr 2012 15:11|
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