Boldin, Mark P. and Baltimore, David (2012) MicroRNAs, new effectors and regulators of NF-κB. Immunological Reviews, 246 (S1). pp. 205-220. ISSN 0105-2896 http://resolver.caltech.edu/CaltechAUTHORS:20120430-085843753
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Since its discovery 25 years ago, nuclear factor-κB (NF-κB) has emerged as a transcription factor that controls diverse biological functions, ranging from inflammation to learning and memory. Activation of NF-κB initiates an elaborate genetic program. Some of the NF-κB-driven genes do not encode proteins but rather are precursors to microRNAs. These microRNAs play important roles in the regulation of the inflammatory process, some being inhibitory and others activating. Here, we discuss both the regulation of their expression and the function of some of these non-coding RNA genes. We also include a personal discussion of how NF-κB was first discovered.
|Additional Information:||© 2012 John Wiley & Sons A/S. Article first published online: 21 Mar. 2012. The authors have no conflicts of interest to declare.|
|Subject Keywords:||NF-κB; miRNA; inflammation; autoimmunity; cancer|
|Official Citation:||Boldin, M. P. and Baltimore, D. (2012), MicroRNAs, new effectors and regulators of NF-κB. Immunological Reviews, 246: 205–220. doi: 10.1111/j.1600-065X.2011.01089.x|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Ruth Sustaita|
|Deposited On:||30 Apr 2012 16:34|
|Last Modified:||30 Apr 2012 16:34|
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