Kim, Dae Yu and Fingler, Jeff and Zawadzki, Robert J. and Park, Susanna S. and Morse, Lawrence S. and Schwartz, Daniel M. and Fraser, Scott E. and Werner, John S. (2012) Noninvasive Imaging of the Foveal Avascular Zone with High-Speed, Phase-Variance Optical Coherence Tomography. Investigative Ophthalmology and Visual Science, 53 (1). pp. 85-92. ISSN 0146-0404 http://resolver.caltech.edu/CaltechAUTHORS:20120504-153944508
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Purpose. To demonstrate the application of phase-variance optical coherence tomography (pvOCT) for contrast agent–free in vivo imaging of volumetric retinal microcirculation in the human foveal region and for extraction of foveal avascular zone dimensions. Methods. A custom-built, high-speed Fourier-domain OCT retinal imaging system was used to image retinas of two healthy subjects and eight diabetic patients. Through the acquisition of multiple B-scans for each scan location, phase differences between consecutive scans were extracted and used for phase-variance contrast, identifying motion signals from within blood vessels and capillaries. The en face projection view of the inner retinal layers segmented out from volumetric pvOCT data sets allowed visualization of a perfusion network with the foveal avascular zone (FAZ). In addition, the authors presented 2D retinal perfusion maps with pseudo color-coded depth positions of capillaries. Results. Retinal vascular imaging with pvOCT provides accurate measurements of the FAZ area and its morphology and a volumetric perfusion map of microcapillaries. In this study using two images from each fundus fluorescein angiography (FA) and pvOCT, the measured average areas of the FAZ from two healthy subjects were below 0.22 mm^2, and each of eight diabetic patients had an enlarged FAZ area, larger than 0.22 mm^2. Moreover, the FAZ areas demonstrated a significant correlation (r = 0.91) between measurements from FA and pvOCT. Conclusions. The high-speed pvOCT allows contrast agent–free visualization of capillary networks in the human foveal region that is analogous to fundus FA imaging. This could allow for noninvasive diagnosis and progression monitoring of diabetic retinopathy in clinical settings.
|Additional Information:||© 2012 The Association for Research in Vision and Ophthalmology, Inc. Submitted for publication July 19, 2011; revised October 24, 2011; accepted November 17, 2011. Supported by National Eye Institute Grant EY014743, Research to Prevent Blindness, Beckman Institute, That Man May See Foundation, and Howard Hughes Medical Institute Med-into-Grad Initiative HHMI-MIG 56006769. The authors thank Susan Garcia, Suman Pilli, Sandra Balderas-Mata, and Athanasios Panorgias (Vision Science and Advanced Retinal Imaging Laboratory, Department of Ophthalmology and Vision Science, University of California at Davis Medical Center) for help with OCT data acquisition.|
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|Deposited By:||Tony Diaz|
|Deposited On:||08 May 2012 17:14|
|Last Modified:||08 May 2012 17:14|
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