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Protein phosphorylation in chemotaxis and two-component regulatory systems of bacteria

Bourret, Robert B. and Hess, J. Fred and Borkovich, Katherine A. and Pakula, Andrew A. and Simon, Melvin I. (1989) Protein phosphorylation in chemotaxis and two-component regulatory systems of bacteria. Journal of Biological Chemistry, 264 (13). pp. 7085-7088. ISSN 0021-9258. http://resolver.caltech.edu/CaltechAUTHORS:20120517-080226952

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Abstract

Two-component regulatory systems appear to be widespread in bacteria. Phosphorylation has been demonstrated in three of the known systems and correlated with in vivo function in two cases (Che and Ntr). Although phosphorylation of sensor and regulator proteins has so far been observed exclusively in vitro, transient protein phosphorylation could provide a basis for the mechanism of signal transduction in these bacterial systems. There is currently insufficient evidence, however, to establish the precise functional relationship(s) between the conserved sensor and regulator sequences, phosphorylation, and the detailed mechanism involved in signal transduction via the sensor and regulator proteins.


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http://www.jbc.org/content/264/13/7085PublisherUNSPECIFIED
Additional Information:© 1989 by The American Society of Biochemistry and Molecular Biology, Inc. We thank Narasimhan Gautam, Anna Glasgow, Kelly Hughes, Hong Ma, Mike Strathmann, Greg Wiederrecht, and Tom Wilkie for critical reading of the manuscript.
Record Number:CaltechAUTHORS:20120517-080226952
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20120517-080226952
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:31514
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:23 May 2012 15:58
Last Modified:23 May 2012 15:58

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