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A Lithium-sensitive Regulator of Sperm Flagellar Oscillation Is Activated by cAMP-dependent Phosphorylation

Brokaw, Charles J. (1987) A Lithium-sensitive Regulator of Sperm Flagellar Oscillation Is Activated by cAMP-dependent Phosphorylation. Journal of Cell Biology, 105 (4). pp. 1789-1798. ISSN 0021-9525. PMCID PMC2114665. http://resolver.caltech.edu/CaltechAUTHORS:20120622-085002943

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Abstract

Specific effects of both in vivo activation and in vitro activation by cAMP-dependent phosphorylation on bending wave parameters of demembranated, reactivated, tunicate (Ciona intestinalis) and sea urchin (Lytechinus pictus) sperm flagella can be reversed by exposure to protein phosphatase. The effects of protein phosphatase incubation can be imitated by inclusion of LiCl in the reactivation solutions. The primary effect of cAMP-dependent phosphorylation appears to be activation of a regulatory mechanism controlling flagellar oscillation, rather than activation of the active sliding mechanism. Lithium appears to act on the same regulatory mechanism.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1083/jcb.105.4.1789DOIArticle
http://www.jstor.org/stable/info/1612497JSTORArticle
http://jcb.rupress.org/content/105/4/1789PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2114665/PubMed CentralArticle
Additional Information:© 1987 Rockefeller University Press. After the Initial Publication Period, RUP will grant to the public the non-exclusive right to copy, distribute, or display the Article under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode, or updates thereof. Received for publication 19 March 1987, and in revised form 15 June 1987. The contributions of Sandra Nagayama and Larry Jones to this work were substantial, and are acknowledged with thanks. This work has been supported by grant GM 18711 from the National Institutes of Health.
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Funding AgencyGrant Number
NIHGM 18711
PubMed Central ID:PMC2114665
Record Number:CaltechAUTHORS:20120622-085002943
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20120622-085002943
Official Citation:A Lithium-Sensitive Regulator of Sperm Flagellar Oscillation Is Activated by cAMP-Dependent Phosphorylation Charles J. Brokaw The Journal of Cell Biology , Vol. 105, No. 4, Part 1 (Oct., 1987), pp. 1789-1798
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:32026
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:22 Jun 2012 16:12
Last Modified:02 May 2017 19:02

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