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A Lithium-sensitive Regulator of Sperm Flagellar Oscillation Is Activated by cAMP-dependent Phosphorylation

Brokaw, Charles J. (1987) A Lithium-sensitive Regulator of Sperm Flagellar Oscillation Is Activated by cAMP-dependent Phosphorylation. Journal of Cell Biology, 105 (4). pp. 1789-1798. ISSN 0021-9525.

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Specific effects of both in vivo activation and in vitro activation by cAMP-dependent phosphorylation on bending wave parameters of demembranated, reactivated, tunicate (Ciona intestinalis) and sea urchin (Lytechinus pictus) sperm flagella can be reversed by exposure to protein phosphatase. The effects of protein phosphatase incubation can be imitated by inclusion of LiCl in the reactivation solutions. The primary effect of cAMP-dependent phosphorylation appears to be activation of a regulatory mechanism controlling flagellar oscillation, rather than activation of the active sliding mechanism. Lithium appears to act on the same regulatory mechanism.

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Additional Information:© 1987 Rockefeller University Press. Received for publication 19 March 1987, and in revised form 15 June 1987. The contributions of Sandra Nagayama and Larry Jones to this work were substantial, and are acknowledged with thanks. This work has been supported by grant GM 18711 from the National Institutes of Health.
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NIHGM 18711
Record Number:CaltechAUTHORS:20120622-085002943
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Official Citation:A Lithium-Sensitive Regulator of Sperm Flagellar Oscillation Is Activated by cAMP-Dependent Phosphorylation Charles J. Brokaw The Journal of Cell Biology , Vol. 105, No. 4, Part 1 (Oct., 1987), pp. 1789-1798
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:32026
Deposited By: Ruth Sustaita
Deposited On:22 Jun 2012 16:12
Last Modified:26 Dec 2012 15:22

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