Brokaw, Charles J. (1975) Molecular mechanism for oscillation in flagella and muscle. Proceedings of the National Academy of Sciences of the United States of America, 72 (8). pp. 3102-3106. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:20120725-095601278
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Two-state models for muscle cross-bridges, of the type originally detailed by Andrew Huxley, were examined. Rate functions for cross-bridge attachment and detachment can be chosen which yield a steady-state force-velocity relationship appropriate for the spontaneous generation of oscillatory contractions. Computer simulations have been used to demonstrate oscillation of such cross-bridge systems, and to demonstrate that distribution of this type of local shear oscillation along the length of a flagellum is sufficient for the generation of propagated bending waves.
|Additional Information:||© 1975 National Academy of Sciences. Communicated by Ray D. Owen, June 5, 1975. I am indebted to Dr. T. L. Hill and to Dr. I. R. Gibbons for acquainting me with their work in advance of publication and for helpful comments on this manuscript, and to Dr. T. K. Caughey for a helpful discussion of nonlinear oscillations. This work has been supported by NIH grants which have made possible the computer simulations (GM 21931) and the experimental work (GM 18711) which has stimulated the development of theoretical models.|
|Subject Keywords:||cross-bridges; computer simulation|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Jason Perez|
|Deposited On:||25 Jul 2012 18:30|
|Last Modified:||25 Jul 2012 18:30|
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