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Morphogenesis of Poliovirus II. Demonstration of a New Intermediate, the Proviron

Fernandez-Tomas, Carlos B. and Baltimore, David (1973) Morphogenesis of Poliovirus II. Demonstration of a New Intermediate, the Proviron. Journal of Virology, 12 (5). pp. 1122-1130. ISSN 0022-538X.

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Poliovirus-infected cells contain a previously unrecognized particle which appears to be an intermediate in virion synthesis and therefore has been named proviron. It sediments at about 125S, contains the three procapsid proteins, VP-0, VP-1, and VP-3, and has 35S viral RNA. It is disrupted both by sodium dodecyl sulfate and EDTA but the RNA resists digestion by ribonuclease. Pulsechase experiments and studies employing the virus-specific inhibitor, guanidine, all indicate that the proviron is formed by combination of newly made RNA with the procapsid. Cleavage of VP-0 to form VP-2 and VP-4 follows formation of the provirion and would be the final step in poliovirus morphogenesis.

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Additional Information:© 1973 American Society for Microbiology. Received for publication 21 June 1973. We thank Donna Smoler for expert technical assistance and Alice Huang and Charles Cole for critical reading of the manuscript. This investigation was supported by Public Health Service grant AI-08388 from The National Institute of Allergy and Infectious Diseases. C.B.F. was a post-doctoral fellow of the Damon Runyon Memorial Fund for Cancer Research and D.B. was an American Cancer Society research professor.
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National Institute of Allergy and Infectious Diseases Public Health Service (PHS)AI-08388
Damon Runyan Memorial Fund for Cancer Research posdoctoral fellowshipUNSPECIFIED
American Cancer SocietyUNSPECIFIED
Record Number:CaltechAUTHORS:20120726-100027537
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ID Code:32743
Deposited By: Jason Perez
Deposited On:26 Jul 2012 21:54
Last Modified:23 Aug 2016 10:15

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