Yang, Changhuei and Choma, Michael A. and Lamb, Laura E. and Simon, John D. and Izatt, Joseph A. (2004) Protein-based molecular contrast optical coherence tomography with phytochrome as the contrast agent. Optics Letters, 29 (12). pp. 1396-1398. ISSN 0146-9592 http://resolver.caltech.edu/CaltechAUTHORS:YANol04b
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We report the use of phytochrome A (phyA), a plant protein that can reversibly switch between two states with different absorption maxima (at 660 and 730 nm), as a contrast agent for molecular contrast optical coherence tomography (MCOCT). Our MCOCT scheme builds up a difference image revealing the distribution of phyA within a target sample from pairs of consecutive OCT A-scans acquired at a probe wavelength of 750 nm, both with and without additional illumination of the target sample with 660-nm light. We demonstrate molecular imaging with this new MCOCT modality in a target sample containing a mixture of 0.2% Intralipid and 83 µM of phyA.
|Additional Information:||© 2004 Optical Society of America Received January 2, 2004 This research was supported by National Institutes of Health grant EB000243.|
|Subject Keywords:||Optical coherence tomography; Medical and biological imaging; Molecular spectroscopy; Photochemistry|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Archive Administrator|
|Deposited On:||30 May 2006|
|Last Modified:||26 Dec 2012 08:53|
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