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Regulation of gene expression by DNA binding Py-Im polyamides: Targeting transcription factor-DNA interfaces

Dervan, P. B. (2010) Regulation of gene expression by DNA binding Py-Im polyamides: Targeting transcription factor-DNA interfaces. In: International Chemical Congress of Pacific Basin Societies (Pacifichem 2010), December 15-20, 2010, Honolulu, HI. http://resolver.caltech.edu/CaltechAUTHORS:20120815-154559765

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Abstract

Many human diseases are caused by dysregulated gene expression. The oversupply or overactivity of one or more transcription factors may be required for the survival, growth, and metastatic behavior of all human cancers. Pyrroleimidazole polyamides are synthetic mols. programmed to read the DNA double helix by a set of simple chem. principles. These cell permeable small mols. achieve affinities and specificities comparable to DNA-binding proteins. Research efforts are focused on the modulation of gene expression pathways in cell culture by disruption of transcription factor- DNA interfaces.


Item Type:Conference or Workshop Item (Paper)
Additional Information:© 2012 American Chemical Society.
Record Number:CaltechAUTHORS:20120815-154559765
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20120815-154559765
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:33243
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:15 Aug 2012 23:01
Last Modified:15 Aug 2012 23:01

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