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Fourier-domain low-coherence interferometry for light-scattering spectroscopy

Wax, Adam and Yang, Changhuei and Izatt, Joseph A. (2003) Fourier-domain low-coherence interferometry for light-scattering spectroscopy. Optics Letters, 28 (14). pp. 1230-1232. ISSN 0146-9592.

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We present a novel method for obtaining depth-resolved spectra for determining scatterer size through elastic- scattering properties. Depth resolution is achieved with a white-light source in a Michelson interferometer with the mixed signal and reference fields dispersed by a spectrograph. The spectrum is Fourier transformed to yield the axial spatial cross correlation between the signal and reference fields with near 1 m m depth resolution. Spectral information is obtained by windowing to yield the scattering amplitude as a function of wave number. The technique is demonstrated by determination of the size of polystyrene microspheres in a subsurface layer with subwavelength accuracy. Application of the technique to probing the size of cell nuclei in living epithelial tissues is discussed.

Item Type:Article
Additional Information:© 2003 Optical Society of America Received February 10, 2003
Subject Keywords:Optical coherence tomography; Backscattering; Interferometry
Record Number:CaltechAUTHORS:WAXol03
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:3335
Deposited By: Archive Administrator
Deposited On:31 May 2006
Last Modified:08 Dec 2014 23:20

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