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Signaling through DNA

Barton, Jacqueline K. (2012) Signaling through DNA. In: 244th ACS National Meeting & Exposition, August 19-23, Philadelphia, PA. http://resolver.caltech.edu/CaltechAUTHORS:20120822-080618079

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Abstract

DNA charge transport chem. offers an opportunity to carry out redox chem. at a distance and thus provides a powerful platform for signaling, whether in the design of new sensors or in activating responses across the genome. Many expts. have now shown that DNA-mediated charge transport can arise over long mol. distances but in a reaction that is exquisitely sensitive to perturbations in the DNA base stack. Studies are described to illustrate this chem., to design new DNA-based sensors, and to characterize how DNA-binding proteins utilize DNA charge transport for long range signaling.


Item Type:Conference or Workshop Item (Paper)
Record Number:CaltechAUTHORS:20120822-080618079
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20120822-080618079
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:33433
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:27 Aug 2012 23:15
Last Modified:27 Aug 2012 23:15

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