Barton, Jacqueline K. (2012) Signaling through DNA. In: 244th ACS National Meeting & Exposition, August 19-23, Philadelphia, PA. http://resolver.caltech.edu/CaltechAUTHORS:20120822-080618079
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DNA charge transport chem. offers an opportunity to carry out redox chem. at a distance and thus provides a powerful platform for signaling, whether in the design of new sensors or in activating responses across the genome. Many expts. have now shown that DNA-mediated charge transport can arise over long mol. distances but in a reaction that is exquisitely sensitive to perturbations in the DNA base stack. Studies are described to illustrate this chem., to design new DNA-based sensors, and to characterize how DNA-binding proteins utilize DNA charge transport for long range signaling.
|Item Type:||Conference or Workshop Item (Paper)|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||27 Aug 2012 23:15|
|Last Modified:||25 Jan 2016 20:44|
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